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{"id":2095,"date":"2024-04-09T10:19:30","date_gmt":"2024-04-09T10:19:30","guid":{"rendered":"https:\/\/offhealth.netseven.work\/ricerca\/effects-of-a-new-formulation-of-multiple-action-tear-substitute-on-objective-ocular-surface-parameters-and-ocular-discomfort-symptoms-in-patients-with-dry-eye-disease\/"},"modified":"2024-05-14T13:40:21","modified_gmt":"2024-05-14T13:40:21","slug":"effects-of-a-new-formulation-of-multiple-action-tear-substitute-on-objective-ocular-surface-parameters-and-ocular-discomfort-symptoms-in-patients-with-dry-eye-disease","status":"publish","type":"ricerca","link":"https:\/\/offhealth.netseven.work\/en\/ricerca\/effects-of-a-new-formulation-of-multiple-action-tear-substitute-on-objective-ocular-surface-parameters-and-ocular-discomfort-symptoms-in-patients-with-dry-eye-disease\/","title":{"rendered":"Effects of a New Formulation of Multiple-Action Tear Substitute on Objective Ocular Surface Parameters and Ocular Discomfort Symptoms in Patients with Dry Eye Disease"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Introduction<\/h4>\n\n<p>Dry eye disease (DED) represents one of the most common ocular disorders encountered in clinical practice, with a reported prevalence of 5% to 50% in the adult population.<\/p>\n\n<p>Tear supplementation is the mainstay of the current management of DED. Recently, there has been a progressive shift from simple drugs that add water to complex multi-action combination formulas aimed at disrupting different mechanisms within the vicious cycle of dry eye disease (DED). This study evaluated the efficacy and tolerability of Trimix eye drops (Off Health Italia, Italy), a combination of viscosity-enhancing hyaluronic acid, trehalose, and cationic liposomes comprising stearylamine and phospholipids, in patients with DED.<\/p>\n\n<p>In this study, 25 patients diagnosed with mild to moderate DED were enrolled and treated with Trimix eye drops three times daily for 2 months. <\/p>\n\n<h4 class=\"wp-block-heading\">Improvement of evaluation parameters<\/h4>\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-1024x682.webp\" alt=\"\" class=\"wp-image-1419 lazyload\"\/><noscript><img decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-1024x682.webp\" alt=\"\" class=\"wp-image-1419 lazyload\" srcset=\"https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-1024x682.webp 1024w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-300x200.webp 300w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-768x512.webp 768w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-1536x1024.webp 1536w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-900x600.webp 900w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-750x500.webp 750w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-390x260.webp 390w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-660x440.webp 660w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-370x247.webp 370w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-113x75.webp 113w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-285x190.webp 285w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-525x350.webp 525w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-780x520.webp 780w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-450x300.webp 450w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-470x313.webp 470w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-293x195.webp 293w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-375x250.webp 375w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-150x100.webp 150w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-230x153.webp 230w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-495x330.webp 495w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2-760x507.webp 760w, https:\/\/offhealth.netseven.work\/app\/uploads\/2024\/04\/trimix-gocce-2.webp 1718w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Trimix eye drops<\/strong> is a combination of viscosity-enhancing hyaluronic acid, trehalose, and cationic liposomes comprising stearylamine and phospholipids, which has shown promising results in both animal and ex vivo models of DED.<\/p>\n\n\n\n<p>Trimix eye drops administered three times daily for 2 months resulted in significant improvement in non-invasive break-up time (NIBUT), tear meniscus height (TMH) and lipid layer thickness (LLT) in patients with mild to moderate DED.&#13;\nTrimix eye drops also significantly improved symptoms of ocular discomfort by showing a good tolerability profile.<\/p>\n\n\n\n<p><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Introduction Dry eye disease (DED) represents one of the most common ocular disorders encountered in clinical practice, with a reported&#8230;<\/p>\n","protected":false},"featured_media":1474,"parent":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-2095","ricerca","type-ricerca","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Effects of a New Formulation of Tear Substitute | OffHealth<\/title>\n<meta name=\"description\" content=\"Dry eye disease (DED) represents one of the most common ocular disorders encountered in clinical practice, with a reported 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