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Efficacy of a New Commercial Ocular SprayContaining Oftasecur Citrus Extract for ReducingMicrobial Load in the Conjunctiva of PatientsReceiving Intravitreal Injections

AUTHORS Aldo Vagge - Lorenzo Ferro Desideri - Adriano Carnevali - Chiara Del Noce - Davide Camposampiero - Marina Agrusta - Diego Ponzin - Marco Pellegrini - Sabrina Vaccaro - Massimo Nicolò - Vincenzo Scorcia - Carlo E. Traverso - Giuseppe Giannaccare
DATE 6 August 2021
LINK https://pubmed.ncbi.nlm.nih.gov/34495493/
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Introduction

Control of conjunctival microbial load is critical for patients receiving intravitreal injections (IVT) in order to reduce the risk of endophthalmitis. The purpose of this work was to evaluate the antimicrobial activity of a new commercial eye spray containing Biosecur citrus extract (Oftasecur®, Off Health, Florence, Italy).

IVT endophthalmitis remains a nonnegligible complication, with an estimated incidence ranging from 0.019% to 0.083%. Prophylaxis with a new antiseptic eye spray composed of bioflavonoids (Oftasecur) may reduce the ocular microbial burden of the conjunctiva and potentially further reduce the incidence of IVT-related endophthalmitis.

Prophylactic administration of natural, chemical-free antiseptic compounds such as bioflavonoids may be a viable treatment option in order to reduce the incidence of IVT endophthalmitis, overcoming the drawbacks common to antibiotic agents.

Percentage reduction of positive swabs in OFTASECUR-treated eyes and control eyes:

study results
oftasecur spray

Oftasecur eye spray, administered four times daily starting 4 days before the IVT procedure, has been shown to be effective in significantly reducing the ocular microbial load in the conjunctiva.

Oftasecur eye spray was well tolerated by all subjects in the study group.

Method of use: Apply 1-2 sprays starting 3 times a day, on closed eyelids, at a distance of about 10 cm.